PostNuke is fully compatible with OutSite-In.
In order to take your PostNuke web site on CD or simply offline, we recommend you to:
Modify the "\html\config.php" file by editing your offline files directory:
Find the line starting with:
$pnconfig['dbhost'] =...
and change it to:
$pnconfig['dbhost'] = 'localhost';
(tested with PostNuke 0.764)